Insulin and dietary fructose induce stearoyl-CoA desaturase 1 gene expression of diabetic mice.
KM Waters, JM Ntambi - Journal of Biological Chemistry, 1994 - ASBMB
The transcription and mRNA levels of murine liver stearoyl-CoA desaturase 1 (SCD1) are
induced 11-and 45-fold, respectively, by feeding fasted normal mice with a fat-free, high
carbohydrate diet (Ntambi, JM (1992) J. Biol. Chem. 267, 10925-10930). In this study, we
used streptozotocin-induced diabetic mice to study the regulatory role of carbohydrate and
insulin on expression of the SCD1 gene in liver. Fructose administration to fasted diabetic
mice induced a 2-fold increase in SCD1 mRNA within 6 h and a 23-fold increase within 24 h …
induced 11-and 45-fold, respectively, by feeding fasted normal mice with a fat-free, high
carbohydrate diet (Ntambi, JM (1992) J. Biol. Chem. 267, 10925-10930). In this study, we
used streptozotocin-induced diabetic mice to study the regulatory role of carbohydrate and
insulin on expression of the SCD1 gene in liver. Fructose administration to fasted diabetic
mice induced a 2-fold increase in SCD1 mRNA within 6 h and a 23-fold increase within 24 h …
