[HTML][HTML] Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
M Miyazaki, MJ Jacobson, WC Man, P Cohen… - Journal of Biological …, 2003 - ASBMB
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of
monounsaturated fatty acids. Thus far, three isoforms of SCD (SCD1, SCD2, and SCD3)
have been identified and characterized. Regulation of the SCD1 isoform has been shown to
be an important component of the metabolic actions of leptin in liver, but the effects of leptin
on SCD isoforms in other tissues have not been investigated. We found that although the
mRNA levels of SCD1 and SCD2 were not affected by leptin deficiency in the hearts of ob/ob …
monounsaturated fatty acids. Thus far, three isoforms of SCD (SCD1, SCD2, and SCD3)
have been identified and characterized. Regulation of the SCD1 isoform has been shown to
be an important component of the metabolic actions of leptin in liver, but the effects of leptin
on SCD isoforms in other tissues have not been investigated. We found that although the
mRNA levels of SCD1 and SCD2 were not affected by leptin deficiency in the hearts of ob/ob …
