[HTML][HTML] The carboxyl terminus of type VII collagen mediates antiparallel dimer formation and constitutes a new antigenic epitope for epidermolysis Bullosa acquisita …
M Chen, DR Keene, FK Costa, SH Tahk… - Journal of Biological …, 2001 - ASBMB
Type VII collagen, the major component of anchoring fibrils, consists of a central
collagenous triple-helical domain flanked by two noncollagenous domains, NC1 and NC2.
The NC2 domain has been implicated in catalyzing the antiparallel dimer formation of type
VII procollagen. In this study, we produced the entire 161 amino acids of the NC2 domain
plus 186 amino acids of adjacent collagenous domain (NC2/COL) and purified large
quantities of the recombinant NC2/COL protein. Recombinant NC2/COL readily formed …
collagenous triple-helical domain flanked by two noncollagenous domains, NC1 and NC2.
The NC2 domain has been implicated in catalyzing the antiparallel dimer formation of type
VII procollagen. In this study, we produced the entire 161 amino acids of the NC2 domain
plus 186 amino acids of adjacent collagenous domain (NC2/COL) and purified large
quantities of the recombinant NC2/COL protein. Recombinant NC2/COL readily formed …
