Cellular cholesterol efflux mediated by cyclodextrins
EPC Kilsdonk, PG Yancey, GW Stoudt… - Journal of Biological …, 1995 - ASBMB
In this study, we compared cholesterol efflux mediated by either high density lipoproteins
(HDL 3) or β-cyclodextrins, cyclic oligosaccharides that are able to dissolve lipids in their
hydrophobic core. β-Cyclodextrin, 2-hydroxypropyl-β-cyclodextrin, and methyl-β-cyclodextrin
at 10 mM induced the release of 50-90% of L-cell [3 H] cholesterol after 8 h of incubation,
with a major portion of this cholesterol being released in the first 1-2 h of incubation. The
cholesterol efflux kinetics are different if cells are incubated with HDL 3, which induces a …
(HDL 3) or β-cyclodextrins, cyclic oligosaccharides that are able to dissolve lipids in their
hydrophobic core. β-Cyclodextrin, 2-hydroxypropyl-β-cyclodextrin, and methyl-β-cyclodextrin
at 10 mM induced the release of 50-90% of L-cell [3 H] cholesterol after 8 h of incubation,
with a major portion of this cholesterol being released in the first 1-2 h of incubation. The
cholesterol efflux kinetics are different if cells are incubated with HDL 3, which induces a …
