Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 (∗)
K Iwata, T Seya, Y Yanagi, JM Pesando… - Journal of Biological …, 1995 - ASBMB
The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b
inactivating factor for the protection of host cells from autologous complement attack and as
a receptor for measles virus (MV). MCP consists of four short consensus repeats (SCR)
which are the predominant extracellular structural motif. In the present study, we determined
which of the four SCR of MCP contribute to its function using Chinese hamster ovary cell
clones expressing each SCR deletion mutants. The results were as follows: 1) SCR1 and …
inactivating factor for the protection of host cells from autologous complement attack and as
a receptor for measles virus (MV). MCP consists of four short consensus repeats (SCR)
which are the predominant extracellular structural motif. In the present study, we determined
which of the four SCR of MCP contribute to its function using Chinese hamster ovary cell
clones expressing each SCR deletion mutants. The results were as follows: 1) SCR1 and …
