Abnormal PI3 kinase/Akt signal pathway in vagal afferent neurons and vagus nerve of streptozotocin-diabetic rats
F Cai, CJ Helke - Molecular brain research, 2003 - Elsevier
The PI3 (phosphatidylinositol-3) kinase/Akt (protein kinase B) signal pathway is involved in
the molecular signaling that regulates retrograde axonal transport of neurotrophins in the
nervous system. Previous work showed that a reduced retrograde axonal transport of
endogenous nerve growth factor (NGF) and neurotrophin-3 (NT-3) in the vagus nerve of
diabetic rats occurred in the presence of normal production of neurotrophins and
neurotrophin receptors. To assess the potential involvement of an impaired PI3 kinase/Akt …
the molecular signaling that regulates retrograde axonal transport of neurotrophins in the
nervous system. Previous work showed that a reduced retrograde axonal transport of
endogenous nerve growth factor (NGF) and neurotrophin-3 (NT-3) in the vagus nerve of
diabetic rats occurred in the presence of normal production of neurotrophins and
neurotrophin receptors. To assess the potential involvement of an impaired PI3 kinase/Akt …