Identification and functional reconstitution of the type 2 inositol 1, 4, 5-trisphosphate receptor from ventricular cardiac myocytes
PJ Perez, J Ramos-Franco, M Fill… - Journal of Biological …, 1997 - ASBMB
The inositol 1, 4, 5-trisphosphate receptor (InsP 3 R) is an intracellular Ca 2+ release
channel that mediates the rise in cytoplasmic calcium in response to receptor-activated
production of InsP 3. The InsP 3 R-mediated signaling pathway appears to be ubiquitous
and is involved in many cellular processes including cell division, smooth muscle
contraction, and neuronal signaling. Different regions of the heart also express InsP 3
receptors. We report here that acutely dissociated ventricular myocytes from ferret and rat …
channel that mediates the rise in cytoplasmic calcium in response to receptor-activated
production of InsP 3. The InsP 3 R-mediated signaling pathway appears to be ubiquitous
and is involved in many cellular processes including cell division, smooth muscle
contraction, and neuronal signaling. Different regions of the heart also express InsP 3
receptors. We report here that acutely dissociated ventricular myocytes from ferret and rat …
