[HTML][HTML] Isolation of the SO4-4-GalNAcβ1, 4GlcNAcβ1, 2Manα-specific receptor from rat liver
D Fiete, JU Baenziger - Journal of Biological Chemistry, 1997 - ASBMB
Glycoproteins, such as the glycoprotein hormone lutropin (LH), bear oligosaccharides
terminating with the sequence SO 4-4GalNAcβ1, 4GlcNAcβ1, 2Manα (S4GGnM) and are
rapidly removed from the circulation by a receptor present in hepatic endothelial cells and
Kupffer cells. Rapid removal from the circulation is essential for attaining maximal hormone
activity in vivo. We have isolated a protein from rat liver which has the properties expected
for the S4GGnM-specific receptor (S4GGnM-R). The S4GGnM-R is closely related to the …
terminating with the sequence SO 4-4GalNAcβ1, 4GlcNAcβ1, 2Manα (S4GGnM) and are
rapidly removed from the circulation by a receptor present in hepatic endothelial cells and
Kupffer cells. Rapid removal from the circulation is essential for attaining maximal hormone
activity in vivo. We have isolated a protein from rat liver which has the properties expected
for the S4GGnM-specific receptor (S4GGnM-R). The S4GGnM-R is closely related to the …
