The cDNA encoding the NeuAc(α‐2,6)Gal/GalNAc binding lectin from elderberry (Sambucus nigra) bark (SNAI) was isolated from a cDNA library constructed with mRNA from the bark. Sequence analysis of this lectin cDNA revealed a striking similarity to the previously sequenced type‐2 ribosome‐inactivating proteins from Ricinus communis and Abrus precatorius. Molecular modelling of SNAI further indicated that its structure closely resembles that of ricin. Since SNAI strongly inhibits cell‐free protein synthesis in a rabbit reticulocyte lysate it presumably is a type‐2 ribosome‐inactivating protein. However, SNAI differs from all previously described type‐2 ribosome‐inactivating proteins by its specificity towards NeuAc(α‐2,6)Gal/GalNAc and its unusual molecular structure.