We identified a novel cystic fibrosis transmembrane conductance regulator (CFTR)-
associating, PDZ domain-containing protein, CAL (CFTR associatedligand) containing two
predicted coiled-coiled domains and one PDZ domain. The PDZ domain of CAL binds to the
C terminus of CFTR. Although CAL does not have any predicted transmembrane domains,
CAL is associated with membranes mediated by a region containing the coiled-coil
domains. CAL is located primarily at the Golgi apparatus, co-localizing with trans-Golgi …