Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE2 release from mouse peritoneal macrophages and TNF-α release from rat …
BH Kim, KS Kang, YS Lee - Toxicology letters, 2004 - Elsevier
Anti-inflammatory activity of retinoids has been demonstrated earlier, but their mechanism is
poorly understood. In this study, we examined the effects of retinoids on lipopolysaccharide
(LPS)-induced prostaglandin (PG) E2 production, an indicator of cyclooxygenase (COX)
activity, and COX-2 protein expression in mouse peritoneal macrophages, and tumor
necrosis factor (TNF)-α release in rat peripheral blood mononuclear cell (PBMC) to elucidate
their possible mechanism for anti-inflammation. All-trans retinoic acid (t-RA) and all-trans …
poorly understood. In this study, we examined the effects of retinoids on lipopolysaccharide
(LPS)-induced prostaglandin (PG) E2 production, an indicator of cyclooxygenase (COX)
activity, and COX-2 protein expression in mouse peritoneal macrophages, and tumor
necrosis factor (TNF)-α release in rat peripheral blood mononuclear cell (PBMC) to elucidate
their possible mechanism for anti-inflammation. All-trans retinoic acid (t-RA) and all-trans …