[HTML][HTML] Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-γ1 signaling pathway
The epidermal growth factor receptor (EGFR) ligands, epidermal growth factor (EGF), and
transforming growth factor-α (TGFα) elicit differential postendocytic processing of ligand and
receptor molecules, which impacts long-term cell signaling outcomes. These differences
arise from the higher affinity of the EGF-EGFR interaction versus that of TGFα-EGFR in the
acidic conditions of sorting endosomes. To determine whether EGFR occupancy in
endosomes might also affect short-term signaling events, we examined activation of the …
transforming growth factor-α (TGFα) elicit differential postendocytic processing of ligand and
receptor molecules, which impacts long-term cell signaling outcomes. These differences
arise from the higher affinity of the EGF-EGFR interaction versus that of TGFα-EGFR in the
acidic conditions of sorting endosomes. To determine whether EGFR occupancy in
endosomes might also affect short-term signaling events, we examined activation of the …
