Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry
H Wang, L Feng, J Hu, C Xie, F Wang - Experimental eye research, 2013 - Elsevier
Proliferative diabetic retinopathy (PDR) is a serious microangiopathic complication of
diabetes mellitus and a major cause of blindness in working-age adults. Diabetes-induced
alterations in the vitreous protein composition in diabetic patients with PDR may be
responsible for the presence of PDR. Therefore, we performed a comprehensive proteomic
analysis and compared the protein profiles of vitreous humor from type 2 diabetic patients
with PDR (n= 8) and that from normal human eyes donated for corneal transplant (n= 8) …
diabetes mellitus and a major cause of blindness in working-age adults. Diabetes-induced
alterations in the vitreous protein composition in diabetic patients with PDR may be
responsible for the presence of PDR. Therefore, we performed a comprehensive proteomic
analysis and compared the protein profiles of vitreous humor from type 2 diabetic patients
with PDR (n= 8) and that from normal human eyes donated for corneal transplant (n= 8) …
