Expression of the Major Histocompatibility Complex Class I Molecule Mamu-A*01 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 …
BR Mothé, J Weinfurter, C Wang, W Rehrauer… - Journal of …, 2003 - Am Soc Microbiol
BR Mothé, J Weinfurter, C Wang, W Rehrauer, N Wilson, TM Allen, DB Allison, DI Watkins
Journal of virology, 2003•Am Soc MicrobiolSeveral HLA alleles are associated with attenuated human immunodeficiency virus disease
progression. We explored the relationship between the expression of particular major
histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency
virus SIVmac239-infected macaques. Of the common MHC class I alleles, animals that
expressed Mamu-A* 01 exhibited the best control of viral replication.
progression. We explored the relationship between the expression of particular major
histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency
virus SIVmac239-infected macaques. Of the common MHC class I alleles, animals that
expressed Mamu-A* 01 exhibited the best control of viral replication.
Abstract
Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIVmac239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.
American Society for Microbiology