Background Traumatic brain injury (TBI) is associated with a higher incidence of depression.
The majority of individuals who suffer a TBI are juveniles and young adults, and thus, the risk
of a lifetime of depressive complications is a significant concern. The etiology of increased
TBI-associated depression is unclear but may be inflammatory-related with increased brain
sensitivity to secondary inflammatory challenges (eg, stressors, infection, and injury).
Methods Adult male BALB/c mice received a sham (n= 52) or midline fluid percussion injury …