Gastrointestinal dysfunction in amyotrophic lateral sclerosis

M Toepfer, C Folwaczny, A Klauser, RL … - … Lateral Sclerosis and …, 2000 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, characterized by
progressive loss of motor neurons. However, ALS has been recognized to involve several
non-motor systems. Subclinical involvement of the autonomic system (ie of cardial or
sudomotor regulation) has been described in ALS. Gastrointestinal motor dysfunction can
occur in amyotrophic lateral sclerosis, even if patients do not complain of gastrointestinal
symptoms. New techniques in non-invasive evaluation of gastrointestinal function showed …

Cognitive function in amyotrophic lateral sclerosis

K Abe, H Fujimura, K Toyooka, S Sakoda… - Journal of the …, 1997 - Elsevier
Cognitive function in patients with amyotrophic lateral sclerosis (ALS) has drawn recent
attention. However, the pathogenesis of cognitive dysfunction in patients with ALS remains
uncertain. To explore the underlying mechanism for cognitive dysfunction further, we studied
26 patients with ALS (15 male and 11 female; age from 36 to 67 years) by using
neuropsychological batteries, magnetic resonance imaging (MRI) and single photon
emission computed tomography (SPECT). We also evaluated these patients and an …