Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: association with cerebral inflammation

K Fassbender, R Schmidt, R Mößner… - Archives of …, 1998 - jamanetwork.com
Objective To investigate the association between affective and neuroendocrine
abnormalities, commonly observed in multiple sclerosis, with inflammatory disease activity.
Design Cross-sectional design. Twenty-three patients with definite relapsing-remitting
multiple sclerosis and age-and sex-matched control subjects were investigated. Depression
and anxiety were assessed using structured interviews, self-report measures, andDiagnostic
and Statistical Manual of Mental Disorders, Third Edition, Revisedcriteria. Neurologic …