Polysaccharide A from the capsule of Bacteroides fragilis induces clonal CD4+ T cell expansion
JL Johnson, MB Jones, BA Cobb - Journal of Biological Chemistry, 2015 - ASBMB
For 3 decades, the view of MHCII-dependent antigen presentation has been completely
dominated by peptide antigens despite our 2004 discovery in which MHCII was shown to
present processed fragments of zwitterionic capsular polysaccharides to T cells. Published
findings further demonstrate that polysaccharide A (PSA) from the capsule of Bacteroides
fragilis is a potent activator of CD4+ T cells and that these T cells have important biological
functions, especially in the maintenance of immunological homeostasis. However, little is …
dominated by peptide antigens despite our 2004 discovery in which MHCII was shown to
present processed fragments of zwitterionic capsular polysaccharides to T cells. Published
findings further demonstrate that polysaccharide A (PSA) from the capsule of Bacteroides
fragilis is a potent activator of CD4+ T cells and that these T cells have important biological
functions, especially in the maintenance of immunological homeostasis. However, little is …
