Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion
T Hosoi, Y Okuma, T Matsuda, Y Nomura - Autonomic neuroscience, 2005 - Elsevier
The afferent vagus nerve has been suggested to be an important component for transmitting
peripheral immune signals to the brain. However, there is inconsistent evidence showing
that subdiaphragmatic vagotomy did not inhibit the brain mediated behavioral and neural
effects induced by the peripheral application of lipopolysaccharide (LPS). LPS triggers
innate immune cells through Toll-like receptor 4 (TLR4). In the present study, we found that
TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested …
peripheral immune signals to the brain. However, there is inconsistent evidence showing
that subdiaphragmatic vagotomy did not inhibit the brain mediated behavioral and neural
effects induced by the peripheral application of lipopolysaccharide (LPS). LPS triggers
innate immune cells through Toll-like receptor 4 (TLR4). In the present study, we found that
TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested …
