[HTML][HTML] Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel
D Archary, KE Seaton, JS Passmore, L Werner… - Mucosal …, 2016 - Elsevier
The impact of topical antiretrovirals for pre-exposure prophylaxis on humoral responses
following HIV infection is unknown. Using a binding antibody multiplex assay, we
investigated HIV-specific IgG and IgA responses to envelope glycoproteins, p24 Gag and
p66, in the genital tract (GT) and plasma following HIV acquisition in women assigned to
tenofovir gel (n= 24) and placebo gel (n= 24) in the CAPRISA 004 microbicide trial to assess
if this topical antiretroviral had an impact on mucosal and systemic antibody responses …
following HIV infection is unknown. Using a binding antibody multiplex assay, we
investigated HIV-specific IgG and IgA responses to envelope glycoproteins, p24 Gag and
p66, in the genital tract (GT) and plasma following HIV acquisition in women assigned to
tenofovir gel (n= 24) and placebo gel (n= 24) in the CAPRISA 004 microbicide trial to assess
if this topical antiretroviral had an impact on mucosal and systemic antibody responses …