Autonomic dysregulation as an early pathologic feature of Huntington disease
JL Schultz, LA Harshman, JA Kamholz… - Autonomic …, 2021 - Elsevier
Objective Autonomic nervous system (ANS) dysfunction has been described in adults with
motor-manifest Huntington's Disease (HD) or those who are near their predicted motor
onset. It is unclear if ANS dysfunction is present years prior to the onset of motor symptoms
of HD. To bridge this gap in knowledge, we compared crude markers of ANS function
between children with the gene-expansion that causes HD (GE group) who were decades
from their predicted motor onset and gene-non-expanded children (GNE group). Methods …
motor-manifest Huntington's Disease (HD) or those who are near their predicted motor
onset. It is unclear if ANS dysfunction is present years prior to the onset of motor symptoms
of HD. To bridge this gap in knowledge, we compared crude markers of ANS function
between children with the gene-expansion that causes HD (GE group) who were decades
from their predicted motor onset and gene-non-expanded children (GNE group). Methods …