Deletion of naive T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and …
SM Hess, EF Young, KR Miller, BG Vincent… - Transplant …, 2013 - Elsevier
Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which
arise from diverse genetic disparities between donor and recipient outside the MHC, are an
important cause of rejection of MHC-matched grafts. Because clinically significant responses
appear to be directed at only a few antigens, the selective deletion of naïve T cells
recognizing donor-specific, immunodominant minor H antigens in recipients before
transplantation may be a useful tolerogenic strategy. We have previously demonstrated that …
arise from diverse genetic disparities between donor and recipient outside the MHC, are an
important cause of rejection of MHC-matched grafts. Because clinically significant responses
appear to be directed at only a few antigens, the selective deletion of naïve T cells
recognizing donor-specific, immunodominant minor H antigens in recipients before
transplantation may be a useful tolerogenic strategy. We have previously demonstrated that …