Proteolytic shedding is an important step in the functional down-regulation and turnover of
most membrane proteins at the cell surface. Extracellular matrix metalloproteinase inducer
(EMMPRIN) is a multifunctional glycoprotein that has two Ig-like domains in its extracellular
portion and functions in cell adhesion as an inducer of matrix metalloproteinase (MMP)
expression in surrounding cells. Although the shedding of EMMPRIN is reportedly because
of cleavage by metalloproteinases, the responsible proteases, cleavage sites, and …