Although antiretroviral therapy (ART) has been successful in controlling HIV infection, it does
not provide a permanent cure, requires lifelong treatment, and HIV-positive individuals are
left with social concerns such as stigma. The recent application of T cells to treat cancer and
viral reactivations post-transplant offers a potential strategy to control HIV infection. It is
known that naturally occurring HIV-specific T cells can inhibit HIV initially, but this response
is not sustained in the majority of people living with HIV. Genetically modifying T cells to …