Immune dysregulation and inflammation play a major role in the pathology of age-related
disorders. In an earlier study, the microarray data from our laboratory indicated an increase
in inflammation-related gene expression in the liver with age. We further investigated
immune-related changes in the aged liver and found that the levels of inflammatory
cytokines, chemokines, and inflammatory genes were higher in aged animals.
Immunohistochemical studies showed that immune cells formed clusters or foci in the livers …