[HTML][HTML] Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy
SM Cheung, E Husain, Y Masannat, ID Miller… - British Journal of …, 2020 - nature.com
SM Cheung, E Husain, Y Masannat, ID Miller, K Wahle, SD Heys, J He
British Journal of Cancer, 2020•nature.comBackground Precision medicine in breast cancer demands markers sensitive to early
treatment response. Aerobic glycolysis (AG) upregulates lactate dehydrogenase A (LDH-A)
with elevated lactate production; however, existing approaches for lactate quantification are
either invasive or impractical clinically. Methods Thirty female patients (age 39–78 years, 15
grade II and 15 grade III) with invasive ductal carcinoma were enrolled. Lactate
concentration was quantified from freshly excised whole tumours with double quantum …
treatment response. Aerobic glycolysis (AG) upregulates lactate dehydrogenase A (LDH-A)
with elevated lactate production; however, existing approaches for lactate quantification are
either invasive or impractical clinically. Methods Thirty female patients (age 39–78 years, 15
grade II and 15 grade III) with invasive ductal carcinoma were enrolled. Lactate
concentration was quantified from freshly excised whole tumours with double quantum …
Background
Precision medicine in breast cancer demands markers sensitive to early treatment response. Aerobic glycolysis (AG) upregulates lactate dehydrogenase A (LDH-A) with elevated lactate production; however, existing approaches for lactate quantification are either invasive or impractical clinically.
Methods
Thirty female patients (age 39–78 years, 15 grade II and 15 grade III) with invasive ductal carcinoma were enrolled. Lactate concentration was quantified from freshly excised whole tumours with double quantum filtered (DQF) magnetic resonance spectroscopy (MRS), and Nottingham Prognostic Index (NPI), LDH-A and proliferative marker Ki-67 were assessed histologically.
Results
There was a significantly higher lactate concentration (t = 2.2224, p = 0.0349) in grade III (7.7 ± 2.9 mM) than in grade II (5.5 ± 2.4 mM). Lactate concentration was correlated with NPI (ρ = 0.3618, p = 0.0495), but not with Ki-67 (ρ = 0.3041, p = 0.1023) or tumour size (r = 0.1716, p = 0.3645). Lactate concentration was negatively correlated with LDH-A (ρ = −0.3734, p = 0.0421).
Conclusion
Our results showed that lactate concentration in whole breast tumour from DQF MRS is sensitive to tumour grades and patient prognosis.
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