Although the development and progression of heart failure have traditionally been viewed
as hemodynamic disorders, there is now an increasing awareness that the syndrome of
heart failure cannot be simply and/or precisely defined solely in hemodynamic terms. The
inability of the so-called hemodynamic hypothesis to explain the progression of heart failure
has given rise to the notion that heart failure may progress as a result of the overexpression
of an ensemble of biologically active molecules referred to generically as neurohormones …