Recent insights into the role of tumor necrosis factor in the failing heart
DL Mann - Heart Failure Reviews, 2001 - Springer
Heart Failure Reviews, 2001•Springer
Recent studies have identified the importance of biologically active molecules such as
neurohormones in disease progression in heart failure. More recently it has become
apparent that in addition to neurohormones, another portfolio of biologically active
molecules termed cytokines, are also expressed in the setting of heart failure. This article will
review recent clinical and experimental material which suggests that tumor necrosis factor
(TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by …
neurohormones in disease progression in heart failure. More recently it has become
apparent that in addition to neurohormones, another portfolio of biologically active
molecules termed cytokines, are also expressed in the setting of heart failure. This article will
review recent clinical and experimental material which suggests that tumor necrosis factor
(TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by …
Abstract
Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
Springer
