Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity
EY Plotnikov, OA Grebenchikov, VA Babenko… - Toxicology letters, 2013 - Elsevier
Nephrotoxicity and ototoxicity are the most considerable side effects of aminoglycoside
antibiotics, such as gentamicin that seriously limits its application in medicine. The major
mechanism of negative effect of gentamicin on kidney cells involves damage of
mitochondria and induction of an oxidative stress that causes cell death resulting in kidney
dysfunction. In this work we compared effects of the lithium ions and δ-opioid receptors
agonist, dalargin on gentamicin-induced kidney injury. It was revealed that LiCl and dalargin …
antibiotics, such as gentamicin that seriously limits its application in medicine. The major
mechanism of negative effect of gentamicin on kidney cells involves damage of
mitochondria and induction of an oxidative stress that causes cell death resulting in kidney
dysfunction. In this work we compared effects of the lithium ions and δ-opioid receptors
agonist, dalargin on gentamicin-induced kidney injury. It was revealed that LiCl and dalargin …