Lithium in the kidney: friend and foe?
M Alsady, R Baumgarten, PMT Deen… - Journal of the American …, 2016 - journals.lww.com
Trace amounts of lithium are essential for our physical and mental health, and administration
of lithium has improved the quality of life of millions of patients with bipolar disorder for> 60
years. However, in a substantial number of patients with bipolar disorder, long–term lithium
therapy comes at the cost of severe renal side effects, including nephrogenic diabetes
insipidus and rarely, ESRD. Although the mechanisms underlying the lithium–induced renal
pathologies are becoming clearer, several recent animal studies revealed that short-term …
of lithium has improved the quality of life of millions of patients with bipolar disorder for> 60
years. However, in a substantial number of patients with bipolar disorder, long–term lithium
therapy comes at the cost of severe renal side effects, including nephrogenic diabetes
insipidus and rarely, ESRD. Although the mechanisms underlying the lithium–induced renal
pathologies are becoming clearer, several recent animal studies revealed that short-term …