p16: cycling off the beaten path
ABSTRACT p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against
tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well
delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize
non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.
tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well
delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize
non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.
Abstract
p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.
Taylor & Francis Online