[HTML][HTML] Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function
VH Flood, KD Friedman, JC Gill, PA Morateck… - Journal of Thrombosis …, 2009 - Elsevier
Summary Background: Type 2M von Willebrand disease (VWD) is characterized by a
qualitative defect in von Willebrand factor (VWF) and diagnosed by a disproportionate
decrease in VWF ristocetin cofactor activity (VWF: RCo) as compared with VWF antigen
(VWF: Ag). Objective: We report here on the spurious diagnosis of VWD in a patient with a
sequence variation in the ristocetin‐binding domain of VWF. Patients/methods: The index
case had a VWF: RCo of 11 IU dL− 1, with VWF: RCo/VWF: Ag ratio of 0.09. DNA …
qualitative defect in von Willebrand factor (VWF) and diagnosed by a disproportionate
decrease in VWF ristocetin cofactor activity (VWF: RCo) as compared with VWF antigen
(VWF: Ag). Objective: We report here on the spurious diagnosis of VWD in a patient with a
sequence variation in the ristocetin‐binding domain of VWF. Patients/methods: The index
case had a VWF: RCo of 11 IU dL− 1, with VWF: RCo/VWF: Ag ratio of 0.09. DNA …
