[HTML][HTML] Lipopolysaccharide (LPS)-induced autophagy is responsible for enhanced osteoclastogenesis
OJ Sul, HJ Park, HJ Son, HS Choi - Molecules and Cells, 2017 - Elsevier
We hypothesized that inflammation affects number and activity of osteoclasts (OCs) via
enhancing autophagy. Lipopolysaccharide (LPS) induced autophagy, osteoclastogenesis,
and cytoplasmic reactive oxygen species (ROS) in bone marrow-derived macrophages that
were pre-stimulated with receptor activator of nuclear factor-κB ligand. An autophagy
inhibitor, 3-methyladenine (3-MA) decreased LPS-induced OC formation and bone
resorption, indicating that autophagy is responsible for increasing number and activity of …
enhancing autophagy. Lipopolysaccharide (LPS) induced autophagy, osteoclastogenesis,
and cytoplasmic reactive oxygen species (ROS) in bone marrow-derived macrophages that
were pre-stimulated with receptor activator of nuclear factor-κB ligand. An autophagy
inhibitor, 3-methyladenine (3-MA) decreased LPS-induced OC formation and bone
resorption, indicating that autophagy is responsible for increasing number and activity of …
