Senescent cells have undergone permanent growth arrest, adopt an altered secretory
phenotype, and accumulate in the kidney and other organs with ageing and injury.
Senescence has diverse physiologic roles and experimental studies support its importance
in nephrogenesis, successful tissue repair, and in opposing malignant transformation.
However, recent murine studies have shown that depletion of chronically senescent cells
extends healthy lifespan and delays age-associated disease—implicating senescence and …