Tubular GM-CSF promotes late MCP-1/CCR2-mediated fibrosis and inflammation after ischemia/reperfusion injury
L Xu, D Sharkey, LG Cantley - Journal of the American Society of …, 2019 - journals.lww.com
Background After bilateral kidney ischemia/reperfusion injury (IRI), monocytes infiltrate the
kidney and differentiate into proinflammatory macrophages in response to the initial kidney
damage, and then transition to a form that promotes kidney repair. In the setting of unilateral
IRI (U-IRI), however, we have previously shown that macrophages persist beyond the time of
repair and may promote fibrosis. Methods Macrophage homing/survival signals were
determined at 14 days after injury in mice subjected to U-IRI and in vitro using coculture of …
kidney and differentiate into proinflammatory macrophages in response to the initial kidney
damage, and then transition to a form that promotes kidney repair. In the setting of unilateral
IRI (U-IRI), however, we have previously shown that macrophages persist beyond the time of
repair and may promote fibrosis. Methods Macrophage homing/survival signals were
determined at 14 days after injury in mice subjected to U-IRI and in vitro using coculture of …