Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the
aging brain has identified cellular senescence as a critical risk factor of neurodegeneration
and cognitive decline. Associations of cellular senescence with neurodegenerative diseases
like Alzheimer's disease, Down syndrome, Parkinson's disease, and multiple sclerosis are
evident in an extensive body of literature generated over decades of research on aging …