Immune cells with a senescence-associated secretory phenotype increase in the blood of
elderly individuals or individuals with age-associated diseases or with infections. Although
senescent immune cells do not proliferate, they are transcriptionally and metabolically active
and affect the microenvironment through the secretion of pro-inflammatory mediators. An
age-driven increase in senescent B, T and NK cells has been reported and the function of
these cells has been characterized. Results published by different groups have …