[HTML][HTML] CD8α+ β− and CD8α+ β+ plasmacytoid dendritic cells induce Foxp3+ regulatory T cells and prevent the induction of airway hyper-reactivity
V Lombardi, AO Speak, J Kerzerho, N Szely… - Mucosal …, 2012 - Elsevier
Dendritic cells (DCs) control the balance between protection against pathogens and
tolerance to innocuous or self-antigens. Here, we demonstrate for the first time that mouse
plasmacytoid DCs (pDCs) can be segregated into three distinct populations, exhibiting
phenotypic and functional differences, according to their surface expression of CD8α or
CD8β as CD8α− β−, CD8α+ β−, or CD8α+ β+. In a mouse model of lung inflammation,
adoptive transfer of CD8α+ β− or CD8α+ β+ pDCs prevents the development of airway hyper …
tolerance to innocuous or self-antigens. Here, we demonstrate for the first time that mouse
plasmacytoid DCs (pDCs) can be segregated into three distinct populations, exhibiting
phenotypic and functional differences, according to their surface expression of CD8α or
CD8β as CD8α− β−, CD8α+ β−, or CD8α+ β+. In a mouse model of lung inflammation,
adoptive transfer of CD8α+ β− or CD8α+ β+ pDCs prevents the development of airway hyper …