Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors
K Yoshida, JB Cologne, K Cordova, M Misumi… - Experimental …, 2017 - Elsevier
Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust
data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide
antigens, including viral and tumor antigens. The human TCR repertoire declines with age,
but this decline has not been fully investigated longitudinally in individuals. Using a deep
sequencing approach, we analyzed TCRβ repertoires longitudinally over approximately 20
years, with ages ranging from 23 to 50 years at the start (23 to 65 years overall), in …
data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide
antigens, including viral and tumor antigens. The human TCR repertoire declines with age,
but this decline has not been fully investigated longitudinally in individuals. Using a deep
sequencing approach, we analyzed TCRβ repertoires longitudinally over approximately 20
years, with ages ranging from 23 to 50 years at the start (23 to 65 years overall), in …