Cytochrome b5 and NADH cytochrome b5 reductase: genotype–phenotype correlations for hydroxylamine reduction
JC Sacco, LA Trepanier - Pharmacogenetics and genomics, 2010 - journals.lww.com
Objectives NADH cytochrome b 5 reductase (b5R) and cytochrome b 5 (b5) catalyze the
reduction of sulfamethoxazole hydroxylamine (SMX-HA), which can contribute to
sulfonamide hypersensitivity, to the parent drug sulfamethoxazole. Variability in
hydroxylamine reduction could thus play a role in adverse drug reactions. The aim of this
study was to characterize variability in SMX-HA reduction in 111 human livers, and
investigate its association with single nucleotide polymorphisms (SNPs) in b5 and b5R …
reduction of sulfamethoxazole hydroxylamine (SMX-HA), which can contribute to
sulfonamide hypersensitivity, to the parent drug sulfamethoxazole. Variability in
hydroxylamine reduction could thus play a role in adverse drug reactions. The aim of this
study was to characterize variability in SMX-HA reduction in 111 human livers, and
investigate its association with single nucleotide polymorphisms (SNPs) in b5 and b5R …