Adrenergic polymorphisms and survival in African Americans with heart failure: results from A-HeFT
AE Johnson, K Hanley-Yanez, CW Yancy… - Journal of cardiac …, 2019 - Elsevier
Background Polymorphisms in adrenergic signaling affect the molecular function of
adrenergic receptors and related proteins. The β1 adrenergic receptor (ADRB1) Arg389Gly,
G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T,
and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in
prevalence by ethnicity. Their combined effect within black cohorts remains unknown.
Methods and Results We analyzed subjects from the African American Heart Failure Trial (A …
adrenergic receptors and related proteins. The β1 adrenergic receptor (ADRB1) Arg389Gly,
G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T,
and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in
prevalence by ethnicity. Their combined effect within black cohorts remains unknown.
Methods and Results We analyzed subjects from the African American Heart Failure Trial (A …