Evaluation of optical imaging agents in a fluorescence-guided surgical model of head and neck cancer
AC Prince, LS Moore, KE Tipirneni, T Ramesh… - Surgical oncology, 2018 - Elsevier
Background Tumor proliferation often occurs from pathologic receptor upregulation. These
receptors provide unique targets for near-infrared (NIR) probes that have fluorescence-
guided surgery (FGS) applications. We demonstrate the use of three smart-targeted probes
in a model of head and neck squamous cell carcinoma. Methods A dose escalation study
was performed using IntegriSense750, ProSense750EX, and ProSense750FAST in mice
(n= 5) bearing luciferase-positive SCC-1 flank xenograft tumors. Whole body fluorescence …
receptors provide unique targets for near-infrared (NIR) probes that have fluorescence-
guided surgery (FGS) applications. We demonstrate the use of three smart-targeted probes
in a model of head and neck squamous cell carcinoma. Methods A dose escalation study
was performed using IntegriSense750, ProSense750EX, and ProSense750FAST in mice
(n= 5) bearing luciferase-positive SCC-1 flank xenograft tumors. Whole body fluorescence …