Over the last three decades, monoclonal antibodies have made a dramatic transformation
from scientific tools to powerful human therapeutics. At present, approximately 30
therapeutic monoclonal antibodies are marketed in the United States and Europe in a
variety of indications, with sales in the US alone reaching approximately $18.5 billion in
2010. This review describes how antibody engineering has revolutionized drug discovery
and what are considered the key areas for future development in the monoclonal antibody …