Mitigation of primary graft dysfunction in lung transplantation: current understanding and hopes for the future
BJ Wilkey, BA Abrams - Seminars in Cardiothoracic and …, 2020 - journals.sagepub.com
BJ Wilkey, BA Abrams
Seminars in Cardiothoracic and Vascular Anesthesia, 2020•journals.sagepub.comPrimary graft dysfunction (PGD) is a form of acute lung injury that develops within the first 72
hours after lung transplantation. The overall incidence of PGD is estimated to be around
30%, and the 30-day mortality for grade 3 PGD around 36%. PGD is also associated with the
development of bronchiolitis obliterans syndrome, a specific form of chronic lung allograft
dysfunction. In this article, we will discuss perioperative strategies for PGD prevention as
well as possible future avenues for prevention and treatment.
hours after lung transplantation. The overall incidence of PGD is estimated to be around
30%, and the 30-day mortality for grade 3 PGD around 36%. PGD is also associated with the
development of bronchiolitis obliterans syndrome, a specific form of chronic lung allograft
dysfunction. In this article, we will discuss perioperative strategies for PGD prevention as
well as possible future avenues for prevention and treatment.
Primary graft dysfunction (PGD) is a form of acute lung injury that develops within the first 72 hours after lung transplantation. The overall incidence of PGD is estimated to be around 30%, and the 30-day mortality for grade 3 PGD around 36%. PGD is also associated with the development of bronchiolitis obliterans syndrome, a specific form of chronic lung allograft dysfunction. In this article, we will discuss perioperative strategies for PGD prevention as well as possible future avenues for prevention and treatment.
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