Indoleamine 2, 3-dioxygenase: distribution and function in the developing human placenta
Y Kudo, CAR Boyd, I Spyropoulou… - Journal of reproductive …, 2004 - Elsevier
Studies in mice have suggested that the placenta is protected from immune rejection by
maternal T cells by means of localised indoleamine 2, 3-dioxygenase dependent depletion
of tryptophan. To determine whether such mechanisms might operate in the human
placenta, we have studied the physiological importance of human placental indoleamine 2,
3-dioxygenase immunohistochemically and functionally. Indoleamine 2, 3-dioxygenase is
detectable immunohistochemically from day 6 human blastocysts and thereafter throughout …
maternal T cells by means of localised indoleamine 2, 3-dioxygenase dependent depletion
of tryptophan. To determine whether such mechanisms might operate in the human
placenta, we have studied the physiological importance of human placental indoleamine 2,
3-dioxygenase immunohistochemically and functionally. Indoleamine 2, 3-dioxygenase is
detectable immunohistochemically from day 6 human blastocysts and thereafter throughout …