Plasma volume determination in normal and preeclamptic pregnancies

PM Hays, DP Cruikshank, LJ Dunn - American journal of obstetrics and …, 1985 - Elsevier
To determine the clinical usefulness of plasma volume determinations, we measured
plasma volume serially throughout pregnancy with the use of the Evans blue dye-dilution
technique in 20 subjects with normal pregnancies. In comparison, four preeclamptic subjects
were studied. In preeclamptic subjects compared to normal subjects, plasma volume was
reduced (1763±216 versus 2345±198 ml/m 2, p< 0.011). Two normotensive subjects who
subsequently developed preeclampsia had reduced plasma volumes prior to the onset of …