Human regulatory B cells control the TFH cell response
Background Follicular helper T (T FH) cells support terminal B-cell differentiation. Human
regulatory B (Breg) cells modulate cellular responses, but their control of T FH cell–
dependent humoral immune responses is unknown. Objective We sought to assess the role
of Breg cells on T FH cell development and function. Methods Human T cells were
polyclonally stimulated in the presence of IL-12 and IL-21 to generate T FH cells. They were
cocultured with B cells to induce their terminal differentiation. Breg cells were included in …
regulatory B (Breg) cells modulate cellular responses, but their control of T FH cell–
dependent humoral immune responses is unknown. Objective We sought to assess the role
of Breg cells on T FH cell development and function. Methods Human T cells were
polyclonally stimulated in the presence of IL-12 and IL-21 to generate T FH cells. They were
cocultured with B cells to induce their terminal differentiation. Breg cells were included in …