Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury
Z Zhang, D Li, L Xu, HP Li - Brain Research Bulletin, 2019 - Elsevier
Traumatic brain injury (TBI) triggers neuronal death mechanisms that significantly induce
neuronal loss and neurological dysfunction. Our previous study revealed that Sirt1 could
improve the neuroprotective effect by reducing the astrocyte activation after TBI.
Nevertheless, the underlying mechanisms of Sirt1 attenuating astrocyte activation still
remain unclear. The following study examined whether the protection of Sirt1 in nigrostriatal
pathway injury is associated with autophagy regulation. We established a nigrostriatal …
neuronal loss and neurological dysfunction. Our previous study revealed that Sirt1 could
improve the neuroprotective effect by reducing the astrocyte activation after TBI.
Nevertheless, the underlying mechanisms of Sirt1 attenuating astrocyte activation still
remain unclear. The following study examined whether the protection of Sirt1 in nigrostriatal
pathway injury is associated with autophagy regulation. We established a nigrostriatal …