Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes
Y Cheng, H Takeuchi, Y Sonobe, S Jin, Y Wang… - Journal of …, 2014 - Elsevier
Abstract Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases.
Here we investigated the protective functions of SIRT1 in astrocytes, which are the most
abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the
expression levels of pro-inflammatory cytokines and increased the expression levels of
superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased
the acetylation of forkhead box protein O4, decreased the expression levels of superoxide …
Here we investigated the protective functions of SIRT1 in astrocytes, which are the most
abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the
expression levels of pro-inflammatory cytokines and increased the expression levels of
superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased
the acetylation of forkhead box protein O4, decreased the expression levels of superoxide …