Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage
S Yu, X Wang, S Lei, X Chen, Y Liu, Y Zhou… - Neurochemistry …, 2015 - Elsevier
Astrocytes appear to be important regulators of the inflammatory events that occur in stroke.
Sulfiredoxin-1 (Srxn1), an endogenous antioxidant protein, exhibits neuroprotective effects.
Although the mechanism by which Srxn1 negatively regulates oxidative and apoptotic
pathways has been extensively characterized, the impact of Srxn1 on inflammation has not
been well studied. In this study, we used oxygen-glucose deprivation followed by recovery
(OGD/R) and hydrogen peroxide (H 2 O 2) to mimic stress from cerebral ischemic damage …
Sulfiredoxin-1 (Srxn1), an endogenous antioxidant protein, exhibits neuroprotective effects.
Although the mechanism by which Srxn1 negatively regulates oxidative and apoptotic
pathways has been extensively characterized, the impact of Srxn1 on inflammation has not
been well studied. In this study, we used oxygen-glucose deprivation followed by recovery
(OGD/R) and hydrogen peroxide (H 2 O 2) to mimic stress from cerebral ischemic damage …